Investigating the amount of changes in VO2-Max in response to aerobic exercise among careers of different genotypes of HIF-1α gene

Abstract Introduction: The significant role of HIF-1α gene in adjustment to aerobic exercise has been proved. Although, we have not informed by accurate data about different genotypes of this gene. Therefore, the aim of this study was to investigate the relationship between different genotypes of HIF-1α gene with changes in aerobic capacity following aerobic exercise in obese women. Methods:  This study was a practical semi-experimental development research. 23 inactive women (height 157 ± 2/7 cm, weight 74 ± 1/8 kg, age 38 ± 5/4 years, BMI 32 ± 2/4 kg / m2) were selected non-purposefully available. Eight weeks of aerobic exercise including 5 sessions per week and 30 minutes per session with increased intensity (55% to 75% of maximal heart rate) participated, measured before and after aerobic exercise (VO2max) by Bruce Test, Saliva Sample of subjects in 24-hour fasting position to determine genotypes (CC and CT) HIF-1α gene was collected and sent to the laboratory to compare aerobic parallelism between different genotypes Leven Statistical Method was used to correlation of variances and independent T-test was used for changes in aerobic capacity of HIF-1a genotypes. Results: The findings of the research showed that aerobic capacity increased in CC and CT genotypes of the HIF1-α gene. There was no significant difference between the two genotype groups, including the CC genotype (P=0.79) and the CT genotype (P=0.544). Conclusion:  Eight weeks of aerobic training increased aerobic capacity in inactive obese women and but it does not seem that there is a difference between the association of different HIF-1α genotypes with aerobic capacity and these changes.